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- 英文名:
Recombinant Human MHC class I chain-related gene B
- 库存:
100
- 供应商:
艾美捷科技
- 规格:
10ug///1mg///2ug
【MICB】重组人MHC I类链相关基因B,Recombinant Human MHC class I chain-related gene B,MICB
产品名称:【MICB】重组人MHC I类链相关基因B-Recombinant Human MHC class I chain-related gene B 产品货号:PRO-368 产品规格:10ug///1mg///2ug 来源宿主:大肠杆菌中重组表达
保存建议:【MICB】重组人MHC I类链相关基因B-Recombinant Human MHC class I chain-related gene BLyophilized MICB although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution MICB should be stored at 4℃ between 2-7 days and for future use below-18℃.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
背景资料:MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, ?? T cells, and CD8+ ?? T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.
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文献和实验Molecular Typing of the MHC Class I Chain-Related Gene Locus
The human major histocompatibility complex (MHC) class I chain-related genes A and B (MICA and MICB ) are located within the human leukocyte antigen (HLA) class I region of chromosome 6 (1 ). Their organization, expression, and products
into three regions, denoted class I, II, and III. The HLA class II gene complex is approx 1000 kb in length and is arranged into three main subregions (HLA-DP, −DQ, and −DR), each of which contains genes of two types, A and B. The A genes encode α-polypeptides and B
to result predominately from a human anti-mouse major histocompatibility complex (MHC) class II reactivity. Our recent development of NOD-scid IL2rγ null β2m null and NOD-scid IL2rγ null Ab null stocks of mice now make it possible to investigate
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