【LA / SS-B】重组人LA / SS-B蛋白,Reco

【LA / SS-B】重组人LA / SS-B蛋白，Recombinant Human LA / SS-B，LA/SS-B

产品名称：【LA / SS-B】重组人LA / SS-B蛋白-Recombinant Human LA / SS-B

产品货号：PRO-327

产品规格：1mg///20ug///5ug

来源宿主：昆虫Sf9细胞中重组表达

保存建议：【LA / SS-B】重组人LA / SS-B蛋白-Recombinant Human LA / SS-BStore at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.

背景资料：The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren’s syndrome patients. La is involved in various aspects of RNA metabolism， including binding and protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA， processing 5-prime and 3-prime ends of pre-tRNA precursors， acting as an RNA chaperone， and binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus and the cytoplasm， where it assumes different roles. In the nucleus， La protein facilitates the production of tRNAs， acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3’UTR of nascent transcripts， aiding in their folding and maturation. In the cytoplasm， La protein facilitates the translation of specific mRNAs， acting as a translation factor. As an RNA binding protein （RBP）， La protein associates with subsets of mRNAs which contain a 5’-terminal oligopyrimidine （5’TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing， guards them from endonuclease digestion， and organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis， which results in many smaller （42kD， 320， and 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren’s Syndrome patients and referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren’s Syndrome， Systemic Lupus Erythematosus （SLE） and Subacute Cutaneous Lupus. Also， there seems to be a correlation between anti-La/SS-B and the absence of nephritis in SLE patients.

点击：【LA / SS-B】重组人LA / SS-B蛋白-Recombinant Human LA / SS-B查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询艾美捷科技有限公司。更多prospec公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

艾美捷科技有限公司，通过提供完整的产品和服务体系、便利的客户关系和供应链管理，为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观:“学习、创新、合作、卓越"。作为一家具有尖端的技术实力、的经营管理水平和完善的市场销售体系的生物高科技企业，总部位于武汉光谷高新技术开发区，服务面向全国。艾美捷科技是集进口试剂、实验室耗材销售、技术服务与合约开发为一体的专业化高科技公司，为用户提供最前沿的专业资讯、完备的产品、整合的解决方案，及优质的物流服务。为了更好的服务客户，公司组建了一支经验丰富的研发团队-艾美捷生物技术中心，进入研发生产阶段，将更优质的产品推荐给国内生物领域的同仁们!