【CSTB】重组人胱氨酸-B,Recombinant Hum

【CSTB】重组人胱氨酸-B，Recombinant Human Cystatin-B，CSTB

产品名称：【CSTB】重组人胱氨酸-B-Recombinant Human Cystatin-B

产品货号：PRO-609

产品规格：1mg///20ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【CSTB】重组人胱氨酸-B-Recombinant Human Cystatin-B Stefin-B although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please prevent freeze-thaw cycles.

背景资料：Type 1 cystatins are also called stefins which function as intracellular thiol protease inhibitors. Cystatin-B protein is able to form a dimer stabilized by noncovalent forces， inhibiting papain and cathepsins l， h and b. CSTB protein protects proteases leakage from lysosomes. Mutations in Stefin-B gene cause primary defects in patients with progressive myoclonic epilepsy （EPM1）， a degenerative disease of the central nervous system. CSTB is overexpressed & elevated in the serum of HCC patients. Cystatin-B in vivo has a polymeric structure which is sensitive to the redox environment. Cystatin-B inhibits bone resorption by down-regulating intracellular cathepsin K activity despite increased osteoclast survival. Protein and mRNA levels of stefin B are significantly lower in atypical benign meningiomas. Stefins-A & Stefin-B which belong to the type-1 Cystatins， are up-regulated in lung tumours and thus able to counteract harmful tumour-associated proteolytic activity. Human stefin-A & Stefin-B form amyloid fibrils. Copper binding by stefin-B reduces amyloid fibril formation. A number of alternatively spliced CSTB isoforms were recognized in patients with progressive myoclonus epilepsy. Decreased CSTB activity in EPM1 pathogenesis is controled by cathepsins through increased activity of cathepsin-S & cathepsin-L.

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