C-Myc抗体|C-Myc Antibody （MYC； B

产品名称：C-Myc抗体|C-Myc Antibody （MYC； BHLHE39； Myc proto-oncogene protein； Class E basic helix-loop-helix protein 39； Proto-oncogene c-Myc； Transcription factor p64）

【产品形式】：艾美捷为您提供的C-Myc抗体产品为无色溶液形式，含有100 ul抗体.该产品浓度为与批次相关，溶解于in 包含有0.09% （W/V） NaN3的PBS缓冲液中.请在收到该C-Myc抗体产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

【背景资料】：c-Myc-， N-Myc- and L-Myc-encoded proteins function in cell proliferation， differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half-lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung， breast and colon carcinomas， while the N-Myc gene has been found amplified in neuroblastoma. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus， including the leucine zipper， the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif （bHLH-Zip） protein designated Max， specifically associates with c-Myc， N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins， Mad and Mxi1， and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.

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关键词：C-Myc，C-Myc抗体