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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
CD-14 Antibody (CT) (CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen=CD14; Monocyte differentiation antigen CD14, urinary f
- 规格:
100 ul
产品名称:CD-14抗体(C末端)|CD-14 Antibody (CT) (CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen=CD14; Monocyte differentiation antigen CD14, urinary f
【产品形式】:艾美捷为您提供的CD-14抗体(C末端)产品为无色溶液形式,含有100 ul抗体.该产品浓度为与批次相关,溶解于包含有0.09% (W/V) NaN3的PBS缓冲液中.请在收到该CD-14抗体(C末端)产品后,将其置于-20 °C冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:Lipopolysaccharide (LPS) elicits the secretion of mediators and cytokines produced by activated macrophages and monocytes. CD14 is a glycosylphosphatidylinositol (GPI)-anchored protein found on the surfaces of monocytes and polymorphonuclear leukocytes. CD14 functions as a receptor for LPS, resulting in the secretion of various proteins. An important component in the LPS activation of monocytes through the CD14 receptor is the “adapter molecule,” lipopolysaccharide binding protein (LBP). There are two forms of CD14, a membrane-associated form (mCD14), and a soluble form (sCD14). mCD14 responds to LPS alone and facilitates the secretion of proteins, while cells not expressing mCD14 fail to respond to LPS. The cells that lack mCD14 respond to LPS/LBP in the presence of sCD14.
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理, 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
点击:CD-14抗体(C末端),查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:CD-14,CD-14抗体(C末端)
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文献和实验Dendritic cells (DC) are widely considered to be the major antigen-presenting cell (APC) type in immune responses. These cells are obtained from adherent cells or are purified CD14+ monocytes from peripheral blood mononuclear cells (PBMC
Dendritic Cell Development from Mobilized Peripheral Blood CD34+Cells
pathway, CD34+ cells mature into committed CD14-CD1a+ precursor cells that give rise to CD1a+ dendritic cells. In a second differentiation pathway, CD34+ cells first develop into bipotential CD14+ CDla precursor cells, which mature into bipotential CD14
、14.6μg/ml)低于Fab’对Raji、Daudi的IC50(45.9μg/ml、39.5μg/ml)。Fab'(50mg/kg,i.v.)和F(ab’)2(50mg/kg,i.p.)对荷瘤鼠瘤块体积的增长有抑制作用。结论 实现了直接在大肠杆菌中高效可溶性分泌表达有活性的抗CD20嵌合抗体Fab’和F(ab’)2的目的。Fab’适于显象,F(ab)2片段的抑制肿瘤生长活性明显高于Fab’,半衰期长于Fab’,更适于治疗。【关键词】B淋巴细胞瘤嵌合抗体Fab’片段 嵌合抗体F(ab)2片段CD
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