RanBP2 蛋白(人) ligase结构域(GST标签)

【产品形式】：艾美捷为您提供的RanBP2 蛋白(人) ligase结构域(GST标签)形式为20mM HEPES, pH 7.3, 110mM KOAc, 2mM Mg(OAc)2, 0.8mM EGTA, 1mM DTT

【背景资料】：SUMOylation of substrate proteins takes place in a manner analogous to that of the ubiquitin conjugation system, utilising E1, E2 and E3 enzymes in an ATP dependent process and often requires a short sequence containing the consensus Ψ-K-X-D/E (where lysine is the modified amino acid, Ψ is a large hydrophobic residue and X is any amino acid residue) on the substrate protein for protein SUMO modification to occur. The nucleoporin RanBP2 has SUMO E3-like activity and directly interacts with Ubc9 and strongly enhances SUMO transfer from Ubc9 to SUMOylation substrates such as Sp100. The E3-like activity is contained within a 33kDa domain of RanBP2 that lacks RING finger motifs (ΔFG) and does not resemble PIAS family proteins. This active domain is capable of both substrate and auto-SUMOylation in vitro. Recombinant human RanBP2 ligase domain expressed with a N-terminal GST-tag. Protein has utility in SUMOylation reactions.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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