20S 蛋白酶体 alpha1亚基 多克隆抗体 | 20S

【产品形式】：艾美捷为您提供的20S 蛋白酶体 alpha1亚基 多克隆抗体经过WB等实验验证。推荐使用稀释比率分别为：WB 1:100-500。

【背景资料】：The alpha1亚基 of the 20S proteasome complex is involved in guarding and controlling access to the catalytic core. Proteasomes are non-lysosomal proteolytic complexes localised primarily in the cytoplasm and in the nucleus of eukaryotic cells. The 26S proteasome structure is composed of a 20S proteasome catalytic core complex and one or two 19S (PA700) regulatory subcomplexes (26S and 30S complexes respectively). The 20S core comprises two copies of 14亚基s (7 alpha亚基s and 7 beta亚基s) arranged in a α7β7β7α7 cylindrical array. Proteolytic activities are determined by the β1 (caspase-like), β2 (trypsin-like) and β5 (chymotrypsin-like)亚基s, access to which is guarded by the α-subunits. The 19S regulatory unit consists of six ATPase and at least ten non-ATPase亚基s that are required for ubiquitinated protein binding, deubiquitination, substrate unfolding and translocation to the 20S catalytic core. Varying catalytic亚基 composition (β1, β1i; β2, β2i; β5, β5i) results in a variety of possible subtypes from full constitutive proteasome (β1, β2, β5) through mixed populations to full inducible / immunoproteasome (β1i, β2i, β5i). Alternative regulatory complexes such as the PA200 and 11S proteasome activators confer different substrate specificities and activity compared to the 19S regulator.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击20S 蛋白酶体 alpha1亚基 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。