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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
Imatinib mesylate
- 供应商:
艾美捷科技有限公司
- 规格:
25mg
【产品形式】:Autophagy activator. BCR-ABL tyrosine kinase inhibitor.
【背景资料】:Potent BCR-ABL tyrosine kinase inhibitor associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Activates autophagy in an ER stress associated manner not involving c-Abl or Bcl-2 activity.
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文献和实验Detection of BCR-ABL Mutations and Resistance to Imatinib Mesylate
The major mechanism of imatinib resistance for patients with chronic myeloid leukemia (CML) is clonal expansion of leukemic cells with mutations in the Bcr-Abl fusion tyrosine kinase that reduce the capacity of imatinib to inhibit kinase
Inhibitors of Cellular Signaling Targets: Designs and Limitations
. Because of their central role in cellular signaling, as well as their primary role in disease progression, protein kinases are attractive therapeutic targets (2 ,3 ). Seven molecules targeting protein kinases, imatinib mesylate (Gleevec) and trastuzumab (Herceptin
Assessment of Drug Transporter Function Using Fluorescent Cell Imaging
on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2‐methoxy‐3‐(4‐(2‐(5‐methyl‐2‐phenyloxazol‐4‐yl)ethoxy)phenyl)propanoic acid (PF‐407288) in mice. Drug Metab. Dispos. 37:946‐955
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