毒胡萝卜素 | Thapsigargin

【产品形式】：Ca2+-ATPases inhibitior. Autophagy inhibitor (autophagosome - lysosome fusion). ER stress / Unfolded Protein Response inducer.

【背景资料】：Potent, cell-permeable, IP3-independent intracellular calcium releaser, through sarco/endoplasmic reticulum Ca2+-ATPases inhibition. ER stress / Unfolded Protein Response inducer so sometimes reported as an autophagy activator (cf. Brefeldin A and tunicamycin). However conflicting data have also been reported suggesting both indirect inhibition of autophagy by thapsigargin through increase of intracytosolic Ca2+ levels and directly by blocking autolysosome formation. As such thapsigarin is currently regarded as an autophagy inhibitor.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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