基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体产品介绍

MMP12可使为纤溶酶原转化为血管稳定因子(angiostatin),是一种重要的肿瘤血管形成的抑制因子。
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
MMP12 was first described in murine macrophages, later in human macrophages, and more recently in other cell types. Also known as metalloelastase, MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts.xy-15418R HBP1HMG盒区内含蛋白1抗体
xy-15419R HBQ1血红蛋白theta亚型1抗体
xy-15420R HBS1Lhbs1样蛋白抗体
xy-15422R HCAP G缩素复合物亚型蛋白3抗体
xy-15423R HCC1RNA结合蛋白39抗体
xy-15424R HCCS全细胞色素C合成酶抗体
xy-15428R HCP1血红素转运蛋白1抗体
xy-15429R HCP5血红素转运蛋白5抗体
xy-15430R HCST造血细胞信号转导蛋白抗体
xy-15433R HDHD1A卤酸脱卤酶样水解酶域内含蛋白1A抗体
xy-15446R HECTD1E3连接酶抑制素受体抗体
xy-15434R HDPTPHis 结构域内含酪氨酸磷酸酶蛋白抗体
xy-15436R HEAB多聚腺苷酸因子Clp1蛋白抗体
xy-15444R heavy chain cardiac Myosin心肌肌球蛋白重链抗体
xy-15445R HECT E3 ubiquitin ligaseHECT E3泛素链接酶抗体
xy-2894R HDAC11组蛋白去乙酰化酶11抗体
xy-3222R Phospho-HSL (Ser959 + Ser960)磷酸化荷尔蒙敏感脂肪酶抗体
xy-15480R Hho1HHO1蛋白抗体
xy-3221R Phospho-HP1 gamma (Ser93)磷酸化染色质相关蛋白1-γ抗体
xy-3223R Phospho-HSL (Ser863)磷酸化荷尔蒙敏感脂肪酶抗体
xy-3171R phospho-Histone H1.4(Thr18)磷酸化组蛋白H1.4抗体
xy-15404R HAGH羟酰谷胱甘肽水解酶蛋白抗体
xy-10329R phospho-HDAC5 (Ser498)磷酸化组蛋白去乙酰化酶5抗体
xy-2271R HCMV/Cytomegalovirus Glycoprotein B人巨细胞病毒抗体
xy-3211R Phospho-HDAC4 (Ser632) + HDAC5 (Ser498) + HDAC7 (Ser486)磷酸化组蛋白去乙酰化酶4/5/7抗体
xy-2896R Phospho-HER2 (Tyr877)磷酸化HER2受体抗体
xy-3358R Phospho-HSL (Ser660)磷酸化荷尔蒙敏感脂肪酶抗体
xy-5728R HURP肝癌上调蛋白抗体
xy-2145R Hrasls3HRAS样抑制因子3抗体
xy-4193R CBS丝氨酸羧甲半胱氨酸合成酶抗体
基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体