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- 克隆性：
单克隆
- 抗体英文名：
Anti-phospho-Src(pTy
- 抗体名：
磷酸化Src原癌基因抗体
磷酸化Src原癌基因抗体产品介绍
Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 and tyrosine 529 (referring to human Src sequence). The tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylated and Src becomes active. Src is a proto oncogene that may play a role in the regulation of embryonic development and cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer.
Immunogen: Synthetic peptide (Human) derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse (tyrosine 534), chicken (tyrosine 527) and frog (tyrosine 525).
mol wt:60kDa
Other Aliases:
Rous sarcoma oncogene; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; Avian sarcoma virus; c SRC; CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA; cSrc; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; OTTHUMP00000030931; OTTHUMP00000174476; OTTHUMP00000174477; p60 Src; p60Src; pp60c src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Protooncogene SRC; protooncogene SRC Rous sarcoma; SRC Oncogene; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC1; v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian; vsrc avian sarcoma (Schmidt Ruppin A2) viral oncogene homologxy-13047R EBP1erbB3结合蛋白1抗体
xy-13048R ECH1烯酰辅酶A水合酶1抗体
xy-13049R ECHDC2烯酰辅酶A水合酶含结构域蛋白2抗体
xy-13050R EDAR肿瘤坏死因子受体超家族成员EDAR抗体
xy-13051R EDC4自身抗原EDC4抗体
xy-13052R UBR5E3泛素蛋白连接酶EDD抗体
xy-13053R EED胚胎外胚层发育蛋白EED抗体
xy-2678R KAT3B/Ep300转录接头蛋白EP300抗体
xy-2397R Endothelial lipase内皮脂肪酶抗体
xy-3978R ENO1MYC启动子结合蛋白1抗体
xy-5121R ERp29内质网蛋白29抗体
xy-5058R ECHS1烯脂酰辅酶A水解酶抗体
xy-3018R phospho-eIF4EBP1 (Ser64)磷酸化4E结合蛋白1抗体
xy-4058R EHHADH三羟酰辅酶A脱氢酶抗体
xy-9803R EML4限制过度增殖相关蛋白EML4抗体
xy-5164R ETS1 associated protein IIETS1相关蛋白2抗体
xy-9011R EFHA1EFHA1蛋白抗体
xy-4076R phospho-E2F1 (Ser364)磷酸化转录因子E2F-1抗体
xy-9013R EFHC1EFHC1蛋白抗体
xy-9014R EFHC2EFHC2蛋白抗体
xy-9015R EFHD1EFHD1蛋白抗体
xy-9016R EF-CBP2突触结合蛋白2抗体
xy-6279R ENPP2核苷酸焦磷酸酶2抗体
xy-2920R ECHS1长链烯脂酰辅酶A水化酶抗体
xy-6273R ENO1+ENO2+ENO3神经元，肌肉特异性烯醇化酶抗体
xy-7541R EDG3内皮分化型G蛋白偶联受体3抗体
xy-6380R ERCC6L发育相关蛋白ERCC6L抗体（乙醇致畸因子）
磷酸化Src原癌基因抗体
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文献和实验细胞中c-abl、ltk、c-kit和其它原癌基因蛋白产物。这些PTKs的确切功能还不清楚。 表8-2 同src家族PTKs相连接的细胞表面蛋白 细胞表面蛋白 细胞类型 src家族PTK TCR-CD3 T Fyn CD2 T Fyn CD4 T Lck CD8 T Lck CD45 T Fyn、Lck BCR B Blk、Lyn(Fyn)、Lck FcγRⅢ（CD16） NK Fyn IL-2R T，NK Lck、Lyn FcεR I 肥大细胞、嗜碱性粒细胞 Yes、Lyn
Nature 子刊：林圣彩、宋尔卫等建立脂质生成与乳腺癌的直接联系
via lipin-1 to breast cancer malignancy 的研究性论文。 宋尔卫院士、林树勇教授等团队参与了这项研究。 该研究发现原癌基因 Src 能够与磷脂酸磷酸酶 LPIN1 相互作用并直接促进肿瘤细胞中的脂质生成，直接将脂质生成与乳腺癌联系起来，也为其他恶性肿瘤发生发展的内在机制探究提供了新的思路。主要内容Src 与 LPIN1 直接相互作用并催化后者磷酸化为鉴定潜在的、与 LPIN1 相互作用的蛋白，研究人员首先使用 CRISPR/Cas9 技术将乳腺癌细胞系 MDAMB-231
-GTP酶激活蛋白（GTPase activating protein,GAP）以及crk、abl和vav原癌基因产物等。 注：GAP:GTPase activating protein,GTP酶激酶活蛋白 SH-2：src homology region2,src同源区2 SH-3：src homology region 3,src同源区3 PLC：phospholipase C,磷脂酶C （二）SH-2结构域的功能 SH-2的主要功能
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