细胞自噬(Autophagy)是一种非凋亡性的程序性细胞死亡即自噬性程序性细胞死亡,进化过程中高度保守,清除降解细胞内受损伤的细胞结构、衰老的细胞器、以及不再需要的生物大分子等,在细胞的生长、发育和疾病发生中起着重要的作用。细胞自噬是一个高效调控过程,特异性激酶和鸟嘌呤核苷酸磷酸酶(GTPases)在调节自噬通道活性中起着关键作用。
ATG4B is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Also known as: APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae) ; AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br