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- 克隆性:
单克隆
- 抗体英文名:
Anti-Cdc2/P34CDC2/CD
- 抗体名:
周期素依赖激酶1抗体
周期素依赖激酶1抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
周期素依赖激酶1抗体产品介绍
Cdc2在细胞分化中起着重要作用,并且在有丝分裂中具有很高的活性.它是一种丝氨酸/苏氨酸激酶, P34 Cdc2不被酪氨酸激酶激活。
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
mol wt:33kDa
Other Aliases:
P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell division control protein 2 homolog; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; DKFZp686L20222; MGC111195; p34 Cdk1; p34 Protein Kinase
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
mol wt:33kDa
Other Aliases:
P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell division control protein 2 homolog; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; DKFZp686L20222; MGC111195; p34 Cdk1; p34 Protein Kinase
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xy-9042R PDZD7PDZ结构域PDZK7蛋白抗体
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文献和实验相关实验
只在siRNA靶向DONSON处理的细胞中下调80%。 在GDF3转染的细胞中,周期素E2只有轻微改变。 如果我们对在相同样品中上调的基因进行分析,那么在两个样品中上调最强烈的是p21,也被称为周期素依赖的激酶抑制剂1a。 当与转染siGFP的对照细胞相比时,p21在GDF3和DONSON siRNA转染细胞中分别上调1.81-3.31倍(图4)。 图4:细胞周期基因表达水平的变化。显示了在RealTime ready细胞周期检测预制板中检测的所选基因表达水平(周期素和周期素依赖的激酶
IL-2R 介导的信号转导把T 细胞推入有丝分裂周期 IL2受体介导的信号转导除了激活STAT 5之外,还通过多种PTK参与的通路,激活其他一些激酶,包括前面信号转导抑制剂部分提到的雷帕霉素作用的底物mT()R激酶和与FK506相结合的FK结合蛋白(FKBP)。这些激酶可以使周期素依赖性激酶(cyclin-dependentklnase,Cdk)家族中的Cdk2活化,并激活周期素E(Cyclln E)。周期素是细胞进入分裂周期并从Gl期向S期转化的重要调节
转录。其中之一是通过蛋白激酶mTOR和RAFT,激活周期素E和周期素依赖激酶2,后两者使T细胞进入细胞分裂周期。
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周期素依赖激酶1抗体
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