β-连环蛋白抗体（β链接素）

β-连环蛋白抗体（β链接素）产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

β-连环蛋白抗体（β链接素）产品介绍

细胞粘附蛋白（Call Adhesion Protein）
β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。
在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。
在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。
This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq].
mol wt:92kDa xy-13454R GMEB1糖皮质激素调节元件结合蛋白1抗体
xy-13456R GMEB2糖皮质激素调节元件结合蛋白2抗体
xy-13457R GMFG胶浆成熟因子γ/GMF-γ抗体
xy-13459R GMP Synthase谷氨酰胺转移酶GMPS抗体
xy-13461R GMPPBGDP甘露糖焦磷酸化酶B抗体
xy-8874R GPBAR1G蛋白偶联胆汁酸受体1
xy-13473R GNPDA1葡萄糖6-磷酸脱氨酶1抗体
xy-13474R GNPDA2葡萄糖6-磷酸脱氨酶2抗体
xy-13475R GNPNAT1葡萄糖6-N-乙酰基转移酶1抗体
xy-10341R GLS1谷氨酰胺酶1抗体
xy-15385R GPR161G蛋白偶联受体GPR161蛋白抗体
xy-15389R GPR180G蛋白偶联受体GPR180蛋白抗体
xy-15395R GPS2G蛋白通路抑制物蛋白2抗体
xy-15388R GPR177G蛋白偶联受体GPR177蛋白抗体
xy-15391R GPR89AG蛋白偶联受体GPR89A蛋白抗体
xy-15393R GPRASP2G蛋白偶联受体GPRSP2蛋白抗体
xy-15394R GPRC5CG蛋白偶联受体GPRC5C蛋白抗体
xy-13464R GNA14G蛋白偶联受体结合蛋白α14/Gα 14 抗体
xy-13465R GNB1LG蛋白β样蛋白抗体
xy-13466R GNB5G蛋白β5/Gβ 5 抗体
xy-13468R GNG13G蛋白γ13/Gγ13 抗体
xy-13469R GNG5G蛋白γ5/Gγ5 抗体
xy-13470R GNGT1G蛋白γ 1/Gγ 1 抗体
xy-13471R GNL2鸟嘌呤核苷酸结合蛋白2抗体
xy-13472R GNL3L鸟嘌呤核苷酸结合蛋白3样蛋白抗体
xy-13476R GNPTAB溶酶体累积病相关蛋白/口吃相关蛋白抗体
xy-13477R GNPTG溶酶体累积病相关蛋白/口吃相关蛋白抗体
xy-13478R GNRH2促性腺激素释放激素2抗体
β-连环蛋白抗体（β链接素）