- 询价
- Abcam
- 中国/美国/德国
- XY-0803R
- 2025年07月13日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
单克隆
- 抗体英文名：
Anti-BRCA1(Breast ca
- 抗体名：
乳腺癌易感基因1抗体（小鼠 大鼠）
检测人BRCA-1抗体是bs-0802R
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
mol wt:205kDa
Other Aliases:
BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53
xy-6475R SGK3丝氨酸/苏氨酸蛋白激酶Sgk3抗体
xy-6849R SLPI分泌型白细胞蛋白酶抑制因子抗体
xym-0861M 2,4-D(24D1)2，4-二氯苯氧乙酸(除草剂)单克隆抗体
xy-7639R SLC14A1尿素转运型糖蛋白抗体
xy-7667R SLTM雌激素诱导的转录调制器抗体
xy-0237R 14-3-3 Alpha + Beta + Gamma + Delta + Epsilon14-3-3蛋白/14-3-3 α/β/γ/δ/ε亚型抗体
xy-0861R 2,4-D2，4-二氯苯氧乙酸(除草剂)抗体
xy-1124R 5-HTR1A5-羟色胺受体1A抗体
xy-1126R 5-HT/5 Hydroxy Tryptophan5羟色胺抗体
xy-1125R 5-HTR1B5-羟色胺受体1B抗体
xy-3502R Synapsin II神经突触素2抗体
xy-9156R RNF142环指蛋白142抗体
xy-1906R SYT3突触结合蛋白3抗体
xy-1131R SNAP25突触相关蛋白25抗体
xy-0113R SOCS1细胞因子信号传导抑制蛋白1抗体
xy-1079R SOD1超氧化物歧化酶1抗体(铜/锌过氧化物歧化酶SOD)
xy-1080R SOD2超氧化物歧化酶2抗体
xy-1132R Somatostatin 28生长抑素抗体
xy-0523R SOX2胚胎干细胞关键蛋白抗体
xy-1900R SSTR4生长抑素受体4抗体
xy-0585R Smad4Smad4抗体
xy-0566R Smad7 + Smad6Smad7抗体
xy-1544R ShhShh信号转导通路膜蛋白受体抗体
xy-1901R STEAP1前列腺跨膜上皮1抗原抗体
xy-1895R SLC39A6雌激素调节蛋白LIV1/锌转运蛋白抗体
xy-1881R Securin垂体肿瘤转化基因抗体
xy-0994R Shiga-Like Toxin Type II Variant猪水肿素(O139)菌体蛋白抗体
xy-1887R SAMDCS-腺苷蛋氨酸脱羧酶抗体
xy-1892R 5-HTR2B5-羟色胺受体2B抗体
乳腺癌易感基因1抗体（小鼠 大鼠）
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验一、SD大鼠的麻醉 1、SD大鼠腹腔麻醉 把异氟烷和脂肪乳混合做成乳化异氟烷，腹腔注射，3分钟麻醉，30分钟清醒。 乳化异氟烷制备：用30%的脂肪乳为载体，在室温下（20℃）应用玻璃瓶法，配制成8%的乳化异氟烷。即将1.2ml的液态异氟烷和21.3ml的30%脂肪乳加入至一个气密性良好的25～30ml玻璃容器内，在振荡器上以2000r/min的速度剧烈震荡30s，静置30s，然后再以2000r/min速度剧烈震荡50min，达到平衡后放置于4℃冰箱保存备用。 乳化异氟烷，大鼠
大鼠麻醉后，背部脱毛，于 T9-T11 胸椎区域消毒，划约 2-3cm 纵行切口，咬除椎板，暴露硬脊膜，将大鼠固定于多功能鼠固定台，应用脊髓打击器撞击骨髓（打击高度 12mm，重量 10g）大鼠出现尾部痉挛性摆动，表明造模成功。造模后，对各组大鼠进行脊髓损伤的行为学评分，利用斜板实验评测动物脊髓损伤后神经功能恢复情况，分析在脊髓损伤不同时期的变化规律。
多在夜间发生。4、大鼠对空气中的粉尘、氨气、硫化氢等极为敏感，易引发呼吸道疾病，一般开放饲养的大鼠主要死因为呼吸道疾病。5、大鼠对各种刺激很敏感，环境条件的微小变化也可引起大鼠的反应，强烈的噪音可导致大鼠恐慌、互相撕咬，带仔母鼠可出现吃仔现象。6、大鼠具有群居优势，同笼多个饲养比单个饲养的大鼠体重增长快、性情温顺、易于捉取，单个饲养的则胆小易惊、不易捕捉。二、解剖学特点1、外观 大鼠外观与小鼠相似,但个体较大。一般成年大鼠体长不小于18～20cm。尾上覆有短毛和环状角质鳞片，数量多于200片。上下颌
技术资料暂无技术资料 索取技术资料
