乳腺癌易感基因1抗体（小鼠 大鼠）

乳腺癌易感基因1抗体（小鼠 大鼠）产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

乳腺癌易感基因1抗体（小鼠 大鼠）产品介绍

BRCA1基因是最早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关。
检测人BRCA-1抗体是bs-0802R
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
mol wt:205kDa
Other Aliases:
BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53

xy-9715R Sox9a转录因子sox9a抗体
xy-6475R SGK3丝氨酸/苏氨酸蛋白激酶Sgk3抗体
xy-6849R SLPI分泌型白细胞蛋白酶抑制因子抗体
xym-0861M 2,4-D(24D1)2，4-二氯苯氧乙酸(除草剂)单克隆抗体
xy-7639R SLC14A1尿素转运型糖蛋白抗体
xy-7667R SLTM雌激素诱导的转录调制器抗体
xy-0237R 14-3-3 Alpha + Beta + Gamma + Delta + Epsilon14-3-3蛋白/14-3-3 α/β/γ/δ/ε亚型抗体
xy-0861R 2,4-D2，4-二氯苯氧乙酸(除草剂)抗体
xy-1124R 5-HTR1A5-羟色胺受体1A抗体
xy-1126R 5-HT/5 Hydroxy Tryptophan5羟色胺抗体
xy-1125R 5-HTR1B5-羟色胺受体1B抗体
xy-3502R Synapsin II神经突触素2抗体
xy-9156R RNF142环指蛋白142抗体
xy-1906R SYT3突触结合蛋白3抗体
xy-1131R SNAP25突触相关蛋白25抗体
xy-0113R SOCS1细胞因子信号传导抑制蛋白1抗体
xy-1079R SOD1超氧化物歧化酶1抗体(铜/锌过氧化物歧化酶SOD)
xy-1080R SOD2超氧化物歧化酶2抗体
xy-1132R Somatostatin 28生长抑素抗体
xy-0523R SOX2胚胎干细胞关键蛋白抗体
xy-1900R SSTR4生长抑素受体4抗体
xy-0585R Smad4Smad4抗体
xy-0566R Smad7 + Smad6Smad7抗体
xy-1544R ShhShh信号转导通路膜蛋白受体抗体
xy-1901R STEAP1前列腺跨膜上皮1抗原抗体
xy-1895R SLC39A6雌激素调节蛋白LIV1/锌转运蛋白抗体
xy-1881R Securin垂体肿瘤转化基因抗体
xy-0994R Shiga-Like Toxin Type II Variant猪水肿素(O139)菌体蛋白抗体
xy-1887R SAMDCS-腺苷蛋氨酸脱羧酶抗体
xy-1892R 5-HTR2B5-羟色胺受体2B抗体
乳腺癌易感基因1抗体（小鼠 大鼠）