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- Biolegend
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- 304606
- 2025年07月12日
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PE anti-human CD56 (NCAM)参数介绍>>>>
| Clone | MEM-188 |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human, Cross-Reactivity*: Cattle (Bovine, Cow), Swine (Pig, Porcine) |
| Immunogen | KG-1 human acute myelogenous leukemia cell line |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| Preparation | The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody. |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change. " |
| Applications | FC - Quality tested |
| Application Notes | Additional reported applications (for the relevant formats) include: immunoprecipitation, immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections, and Western blotting (non-reducing). |
| Application References | 1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. 2. Chen Q, et al. 2010. Proc Natl Acad Sci USA. 106;21783. PubMed" |
| Description | CD56 is a single transmembrane glycoprotein also known as N-CAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate. |
| Storage | The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
品牌介绍：Biolegend公司自2002年成立以来，一直致力于为生物医药研究领域提供一流的，高质量的流式抗体、试剂盒及其它相关产品。公司聚集了一批来自PharMingen的专业杰出人士，建立了一支雄厚技术背景的专业队伍，并通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以最合理的价格为广大客户提供卓越的免疫学和细胞生物学产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。短短几年时间，Biolegend公司得到了飞速发展，已跻身全球最先进的抗体公司行列，并在2009年成为美国哈佛大家的独家抗体供应商！ Biolegend公司的试剂主要包括细胞免疫、细胞因子、趋化因子、粘附分子等及与癌症研究、T 调节细胞研究、干细胞研究、先天免疫研究、细胞周期分析、凋亡研究及特定修饰类抗体等领域相关的试剂，用于流式、ELISA、免疫沉淀、WB、免疫荧光、免疫组化、及体内体外功能学试验。其中，Biolegend公司的流式抗体以其具有较宽范围的荧光选择及较高的性价比，为广大科研工作者所接受！同时，公司配备了一支经验丰富的技术服务队伍，为客户提供完美的配色方案及快速的售后处理服务！
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文献和实验CD56 分子 CD56 常用单克隆抗体或代号： Leu19,NKH1;(NCAM) 主要表达细胞： NK,Tsub [NK] 分子质量(kDa)和结构： gp180(GPI连接,含FN结构域, 功 能：神经细胞粘附分子(N- CAM) 粘附,诱导杀伤活性 CD56 Aka N-CAM (neural cell adhesion molecule), at #11q23 Regulates homophilic
T-cell dependent antigen specific in situ staining (Pe)
if you have them). Let them dry approx 1 hour in a dry atmosphere at RT. Antibodies (anti-Pe) in the sections degrade more rapidly than tissue antigens. Proceed with staining within 24 hours or freeze the slides. Antigen-specific staining: (Pe staining of Pe
，是一个潜在的NK细胞marker。4. lnc-CD56生物学功能研究在dNK细胞中，lnc-CD56与CD56表达正相关，那么lnc-CD56是否正向调控了CD56？因此，研究人员在HEK-293T细胞中用shRNA敲降了lnc-CD56。结果显示，CD56/NCAM1的mRNA表达水平下降。当在CD34+HPCs中转染敲降lnc-CD56载体，研究人员发现CD56+ 的NK细胞数量减少，CD56的荧光表达也减弱。进一步通过nuclear runon实验验证，lnc-CD56的敲降直接影响了CD56
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