HUMAN IP-10 (CXCL10)(H-IP-10)

Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease and Type 1 diabetes mellitus. The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) is a chemoattractant for CXCR3+T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly onactivated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. Recombinant Human IP-10 produced in E.coli is a single,non-glycosylated polypeptide chain containing 77 amino acids and having amolecular mass of 8,516 Dalton.