Anti-Human/Non-Human Primate C

This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known
as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic
cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also
present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the
complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively,
in the classical and alternative complement pathways. In humans, CD35 has been implicated in
a variety of roles, including complement activation, transporting C3 complexes on erythrocytes,
phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization.
Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host
erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated
with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis.

The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus
monkey, olive baboon, and rhesus macaque.