The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane
glycoprotein. CD19 is expressed by B cells during all stages of development excluding
the terminally differentiated plasma cells. Follicular dendritic cells also express CD19.
Together CD21, CD81, Leu13, MHC class II, and CD19 form a multimolecular complex that
associates with BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium
flux and proliferation of B cells.