- ¥1100
- ABGENT
- AP1302a
- 2026年01月06日
- WB IHC FC
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Bax Antibody (BH3 Domain Specific)
- 抗体英文名：
Bax Antibody (BH3 Domain Specific)
- 应用范围：
WB IHC FC
- 适应物种：
H
- 克隆性：
多克隆
- 规格：
100UL
WB, IHC, FCPrimary AccessionQ07812Other AccessionO02703,Q07814ReactivityHumanPredictedBovineIsotypeRabbit IgCalculated MW21184 DaBax Antibody (BH3 Domain Specific) - Additional infoGene ID581Other Names
BAX; BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4Target/Specificity
This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.Dilution
WB~~1:1000
IHC~~1:50~100
FC~~1:10~50Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Precautions
Bax Antibody (BH3 Domain Specific) is for research use only and not for use in diagnostic or therapeutic procedures.Bax Antibody (BH3 Domain Specific) - Protein InformationNameBAXSynonymsBCL2L4Function
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Cellular Location
Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane Isoform Gamma: Cytoplasm.Tissue Location
Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines
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文献和实验Construction of a Human Antibody Domain (VH) Library
), called a “domain antibody”, or “dAb”, is approximately four times smaller than a Fab and half the size of a scFv. Here, we describe the construction of a phage-displayed VH library and an approach to introduce genetic diversity in this library, where both diverse
Intracellular Antibody Capture (IAC) Methods for Single Domain Antibodies
. We describe here the new generation protocol for intracellular antibody capture to facilitate selection of functional single domains. This protocol uses a series of optimized single domain libraries, based on designed intracellular variable (VH or VL) region scaffolds
Improvement of Single Domain Antibody Stability by Disulfide Bond Introduction
antibody repertoire. By introducing this particular disulfide bond within a single domain antibody, the conformational stability can be increased in general. In this chapter it is described how to introduce this extra intra-domain disulfide bond
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