人抗凝血酶III

抗凝血酶III是一种依赖于肝素的丝氨酸蛋白酶抑制剂，是一种重要的抗凝血因子，在血浆中承担着70%的抗凝血酶活性，在維持血液生理性凝血与抗凝血平衡中起着重要的作用。在正常人类血浆中浓度约为0.15mg/ml，即约2.3μM。抗凝血酶III是正常人血浆中最重要的丝氨酸蛋白酶抑制剂，在血栓形成过程中，在肝素的催化下，通过与凝血酶(FIIa)或凝血因子IXa、Xa、XIa、XIIa、纤溶酶等丝氨酸蛋白酶以1:1的比例形成复合物，从而使这些酶失去活性，发挥抗凝作用。

• Molecular Weight: 58,000 Da
• Specific Activity > 6 IU/mg
• Preserved structure and activity of the native protein

Note:1 Plasma Equivalent Unit (PEU) corresponds to the amount of AT in 1 mL of human plasma, or about 150 µg. 1 PEU is equivalent to 1 International Unit (IU) when determined and standardized against the WHO/NIBSC International Standard for Antithrombin from human plasma.

150 µg (1 mL) (1 mL = 1 PEU)

For in vitro use only.

Recommended for any study on heparin and glycol-amino-glycans. Useful for designing heparin assays (clotting or chromogenic) where a source of ATIII is required.