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- 2025年12月05日
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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1177865-17-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥584.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥219.0 |
| 规格： | 5 mg | 产品价格： | ￥464.0 |
| 规格： | 10 mg | 产品价格： | ￥844.0 |
| 规格： | 25 mg | 产品价格： | ￥1740.0 |
| 规格： | 50 mg | 产品价格： | ￥2800.0 |
| 规格： | 100 mg | 产品价格： | ￥4480.0 |
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NSC 23766 trihydrochloride
CAS No. : 1177865-17-6
MCE 国际站：NSC 23766 trihydrochloride
产品活性：NSC 23766 trihydrochloride 是 Rac1 激活的抑制剂。
研究领域：GPCR/G Protein | Apoptosis
In Vitro: NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons.
In Vivo: NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice.
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