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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
A4166; Senaglinide
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
105816-04-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥312.0 |
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 50 mg | 产品价格： | ￥1540.0 |
| 规格： | 100 mg | 产品价格： | ￥2800.0 |
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Nateglinide
CAS No. : 105816-04-4
MCE 国际站：Nateglinide
产品活性：Nateglinide 是 D-苯丙氨酸的一个衍生物，是一种具有口服活性的、短效的促胰岛素释放化合物，也是 DPP IV 的抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+ 通道。Nateglinide 可用于 2 型糖尿病 (非胰岛素依赖的) 的研究。
研究领域：Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点：Potassium Channel | Dipeptidyl Peptidase
In Vitro: Nateglinide inhibits typical recordings of dinitrophenol-induced KATP currents in a concentration-dependent manner. Nateglinide exhibits IC50 values of 7.4 μM and 2.4 μM for 5 mM glucose (G5) and 16 mM (G16) glucose, respectively[2].
In Vivo: Nateglinide (50mg/kg, orally in mice) stimulates human C-peptide secretion in the humanized mice and improved postprandial glucose concentrations[3].
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文献和实验with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study[J]. BMJ,2000,321(7258):405–412. [2]中华医学会糖尿病学分会．中国血糖监测临床应用指南[J]．中华糖尿病杂志, 7(10):603–613. [3]ZhouJ, LiH, ZhangX, et al. Nateglinide and acarbose
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