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- MedChemExpress(MCE)
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- HY-17369
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
150915-40-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥338.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥310.0 |
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 25 mg | 产品价格： | ￥940.0 |
| 规格： | 50 mg | 产品价格： | ￥1450.0 |
| 规格： | 100 mg | 产品价格： | ￥2280.0 |
| 规格： | 500 mg | 产品价格： | ￥5575.0 |
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Tirofiban hydrochloride monohydrate
CAS No. : 150915-40-5
MCE 国际站：Tirofiban hydrochloride monohydrate
产品活性：Tirofiban (L700462) hydrochloride monohydrate 是一种选择性和可逆性的血小板整合素受体 (Gp IIb/IIIa) 拮抗剂，能抑制纤维蛋白原与该受体结合，具有抗血栓活性。Tirofiban hydrochloride monohydrate 可通过诱导 VEGF 的产生来刺激内皮细胞的迁移和增殖。Tirofiban hydrochloride monohydrate 可通过缓解缺血区的心肌微血管结构和内皮功能障碍显著减少心肌无回流和缺血再灌注损伤，从而改善心脏功能。
研究领域：Cytoskeleton
作用靶点：Integrin
In Vitro: Tirofiban hydrochloride monohydrate (0.25, 1, 3 μg/mL; 72 hours) increases proliferation of HAEC cells.
Tirofiban hydrochloride monohydrate (24 hours) closes the scratch of HUVECs migration within 18 hours.
Tirofiban hydrochloride monohydrate (0.25, 1 μg/mL; 1 hour) induces production of VEGF after 30 minutes which can stimulates proliferation of endothelial cells.
In Vivo: Tirofiban hydrochloride monohydrate (60 μg/kg; i.v.; once) shows activity of increasing contraction force, ventricular compliance, and improving heart function by increasing HR, LVESP, dp/dtmax, and reducing LVEDP.
Tirofiban hydrochloride monohydrate (60 μg/kg; i.v.; once) enhances eNOS activity, decreases iNOS activity and reduces area of no-reflow after reperfusion following AMI.Tirofiban hydrochloride monohydrate (50 µg/per; irrigate; once) shows anticoagulant effect with patency rates of 59% at 24 hours after microvascular anastomosis in the crush model.
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