IWP-2,686770-61-6

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IWP-2

CAS No. : 686770-61-6

MCE 国际站：IWP-2

产品活性：IWP-2 是 Wnt 加工和分泌的抑制剂，其 IC₅₀ 为 27 nM。IWP-2 靶向膜结合的 O-酰基转移酶 porcupine (Porcn)，从而阻止关键的 Wnt 配体棕榈糖基化。IWP-2 还是一种具有 ATP 竞争能力的 CK1δ 抑制剂，对于 ^M82FCK1δ 的 IC₅₀ 为 40 nM。

研究领域：Stem Cell/Wnt  |  Cell Cycle/DNA Damage

作用靶点：Wnt  |  Porcupine  |  Casein Kinase

In Vitro: IWP-2 inhibits the proliferation of the investigated cell lines within the single digit μM range. IWP-2 inhibits cell proliferation in A818-6, MiaPaCa2, Panc-1, Panc-89, HT29, HEK293, SW620 and Capan cell with EC₅₀s of 8.96 μM, 1.90 μM, 2.33 μM, 3.86 μM, 4.67 μM, 2.76 μM, 1.90 μM and 2.05 μM, respectively.
Panc-1 cells are either untreated or treated with 2.33 μM IWP-2 for 48 h. In IWP-2 treated cells, the CK1δ kinase peak activity is reduced to approximately 66% residual activity compared to the activity in untreated cells, respectively. IWP-2 reduces the activity of CK1δ in Panc1 cells.

In Vivo: To evaluate the efficacy of IWP-2 in vivo, 200 μL each of IWP-2-liposome or free liposome i separately injected into C57BL/6 mice intraperitoneally about 2 h before injection of a similar volume of either blue-dye-filled latex beads or E. coli DH5α. IWP-2 causes significant reduction in the uptake of blue beads as well as E. coli as assessed by CFUs in peritoneal lavage cells within 2 h. In addition, the levels of TNF-α and IL-6 in the lavage fluid of the corresponding mice are reduced by 2-4-fold compared with control values. Interestingly, IWP-2 even induces a considerable increase in secretion of the anti-inflammatory cytokine IL-10.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Cytoskeleton Compound Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  LY294002  |  Laduviglusib  |  IWR-1  |  Silmitasertib  |  LGK974  |  Wnt-C59  |  MSAB  |  SKL2001  |  Emodin  |  Heparan Sulfate  |  Ellagic acid  |  Adavivint  |  Wogonin  |  Salinomycin  |  Pyrvinium pamoate  |  Echinacoside  |  D4476  |  BML-284  |  NCB-0846  |  Umbralisib  |  iCRT3  |  PF-670462 dihydrochloride  |  FH535  |  Ginkgetin  |  Platycodin D  |  TBB  |  Foxy-5 TFA

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds