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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1390.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 25 mg | 产品价格： | ￥3500.0 |
| 规格： | 50 mg | 产品价格： | ￥4900.0 |
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SAG hydrochloride
CAS No. : 2095432-58-7
MCE 国际站：SAG hydrochloride
产品活性：SAG hydrochloride 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG hydrochloride 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。
研究领域：Stem Cell/Wnt
作用靶点：Smo
In Vitro: SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM and then inhibits expression at higher concentrations.
?SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (Kd) of 59 nM for the SAG/Smo complex.
?SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin.
?SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells.
?SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells.
?SAG (250 nM; 24 h) increases MDAMB231 cells migration.
In Vivo: SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice.
?SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice.
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Refined solution structure of the oligomerization domain of the tumour suppressor p53 (39,40 ) 1SAE, 1SAF, 1SAG, 1SAH, 1SAI, 1SAJ, 1SAK, 1SAL Solution structure determination of a p53
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