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货期:1-2天
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MedChemExpress LLC
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10 mg/50 mg
| 规格: | 10 mg | 产品价格: | ¥11800.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥31860.0 |
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IWP-2 (GMP)
CAS No. : 686770-61-6
MCE 国际站:IWP-2 (GMP)
产品活性:IWP-2 (GMP) 是 GMP 级别的 IWP-2 (HY-13912)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。IWP-2 是 Wnt 加工和分泌的抑制剂,其 IC50 为 27 nM。IWP-2 靶向膜结合的 O-酰基转移酶 porcupine (Porcn),从而阻止 Wnt 配体棕榈酰化。
研究领域:Stem Cell/Wnt
作用靶点:Wnt
In Vitro: IWP-2 (GMP) (2 μM, in the first 4 days of Stage IV induction medium) reprograms human somatic cells to pluripotent stem cells.
IWP-2 (GMP) (5 μM, day 3 to 5) induces cardiac differentiation of hiPSCs.
IWP-2 (GMP) (5 μM, day 1 to 3) increasing the expression of cardiac progenitors and cardiac genes (MYL2, TNNI3, and TNNT2) in hiPSCs.
IWP-2 (GMP) (5 μM, day 5-7) together with PIP-S2 induces cardiac mesoderm differentiates into functional cardiomyocytes.
IWP-2 (GMP) (5 μM, treated at day 3) induces cardiomyocyte differentiation when applied following a pretreatment with Laduviglusib (GMP) (HY-10182G).
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should calibrate pipettes every 6 months. Facilitieswhich operate under GMP regulations should consider calibrationevery 3 months. 3. Thermocyclers are required to perform PCR. There are manymanufacturers making a variety of models. Thermocyclersinclude
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