Nedocromil奈多罗米钠,69049-73-6

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Nedocromil

CAS No. : 69049-73-6

MCE 国际站：Nedocromil

产品活性：Nedocromil 抑制多种介质的作用或形成，包括组胺，白三烯 C₄ (LTC₄) 和前列腺素 D₂ (PGD₂)。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor  |  Leukotriene Receptor  |  Prostaglandin Receptor

In Vitro: Nedocromil inhibits the release of histamine, LTC₄, and PGD₂ from mast cells challenged with antigen (with IC₃₀ values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC₃₀ values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).

In Vivo: Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.

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