Vinpocetine长春西汀,42971-09-5

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Vinpocetine

CAS No. : 42971-09-5

MCE 国际站：Vinpocetine

产品活性：Vinpocetine (Ethyl apovincaminate) 是一种长春花生物碱衍生物，可阻断 Na⁺ 通道。Vinpocetine 抑制 IKK 的 IC₅₀ 值为 17.17 μM。Vinpocetine 还是 PDE 抑制剂，并通过直接靶向 IKK 抑制 NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。

研究领域：Membrane Transporter/Ion Channel  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Sodium Channel  |  IKK  |  Phosphodiesterase (PDE)

In Vitro: Vinpocetine (5-50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced NF-κB-dependent transcriptional activity in a dose-dependent manner with an approximate IC₅₀ value of 25 μM. Vinpocetine do not have a significant effect on cell viability.
?Vinpocetine (50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced up-regulation of TNF-α, IL-1β, IL-8, MCP-1, VCAM-1, ICAM-1and MIP-2 transcripts in several cell types.

In Vivo: Vinpocetine (2.5-10 mg/kg; intraperitoneal injection; C57BL/6 mice) potently inhibits TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and MIP-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation.

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