In Vitro: Almorexant hydrochloride (1 μM) promote tyrosine phosphorylation of SHP2/OX1R complex. ?Almorexant hydrochloride (1 μM) inhibits the cellular growth of AsPC-1 cells.
In Vivo: Almorexant hydrochloride (1.8 μmol/kg, 100 μL; IP, daily) reduces the volume of tumors. ?Almorexant hydrochloride (300 mg/kg, PO, once) can help rats to be fully capable of spatial and avoidance learning. ?Almorexant hydrochloride (30-300 mg/kg) dose-dependently increases rapid eye movement (REM) and non-REM (NREM) sleep and decreases wakefulness apparently without inducing either cataplexy or deficits in next-day performance.