肺癌拷贝数PCR芯片 Lung Cancer Copy Nu

mber PCR Array

价格¥4800

简介Lung Cancer Copy Number PCR Array
地区上海
更新日期2026年01月05日

上海英拜生物科技有限公司

15 年钻石会员

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服务名称：
Lung Cancer Copy Number PCR Array
提供商：
SAB

Human Lung Cancer Copy Number PCR Array
The Human Lung Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human lung tumor DNA. Recent studies have uncovered gene copy number alterations as a major mechanism that contributes to disease initiation and progression. The genes on the array encode transcription factors, receptors, and growth factors that regulate processes such as the cell cycle and DNA damage repair. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and lung cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify lung cancer samples by genotype and help verify lung cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument. The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease. 96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.

Non-Small Cell Lung Cancers (NSCLC): CCND1, CDKN2A, CSMD1, EGFR, KRAS, MET, MYC, PIK3CA.
Lapatinib Sensitivity: CDKN2A.
AKT & PI-3-Kinase Signaling: AKT1, PIK3CA, PTEN.
Apoptosis: TNFRSF6B.
Cell Adhesion & Cytoskeleton: CSMD1, CTNND1.
Cell Cycle: CCND1, CDKN2A, MDM2.
Growth Factors: VEGFA.
RAS Signaling: KRAS.
Transcription Factors: MYC, NKX2-1, NKX2-8, RB1, SKIL, SOX2, TFDP1.
Tyrosine Kinase Receptors: EGFR, IGF1R, KIT, MET, PDGFRA, RB1.

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Applications of Array-CGH for Lung Cancer
This chapter summarizes the current knowledge on gene copy number changes found in lung tumors, and their application in the diagnosis, prognostication, and prediction of response to chemotherapy. Examples of the identification of specific
Ultradense Array CGH and Discovery of Micro-Copy Number Alterations and Gene Fusions in the Cancer Genome
The characterization of molecular alterations specific to cancer facilitates the discovery of predictive and prognostic biomarkers important to targeted therapeutics. Alterations critical to cancer therapeutics include copy number alterations
Genome-wide Copy Number Analysis on GeneChip Platform Using Copy Number Analyzer for Affymetrix GeneChip 2.0 Software
developed for analyzing raw array signals (Copy Number Analyzer for Affymetrix GeneChip v2.0) enable not only accurate and high resolution copy number estimations, but also allelic imbalances commonly found in cancer genomes, which provides a powerful

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肺癌拷贝数PCR芯片 Lung Cancer Copy Number PCR Array

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