肺癌qBiomarker拷贝数PCR芯片Lung Cance

“英拜为您实验加速”
技术服务网址：http://www.yingbio.com/
服务热线：400-696-6643、 18019265738
邮箱：daihp@yingbio.com 、 huizhang1228@foxmail.com


Lung Cancer qBiomarker Copy Number PCR Arrays

肺癌qBiomarker拷贝数PCR芯片

Product	Species	Technology	Cat. No.
Lung Cancer qBiomarker Copy Number PCR Arrays	Human	Copy Number	VAHS-0056Z

The Human Lung Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human lung tumor DNA. Recent studies have uncovered gene copy number alterations as a major mechanism that contributes to disease initiation and progression. The genes on the array encode transcription factors, receptors, and growth factors that regulate processes such as the cell cycle and DNA damage repair. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and lung cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify lung cancer samples by genotype and help verify lung cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.

肺癌qBiomarker拷贝数PCR芯片用于研究人类肺肿瘤相关且发生频繁突变的23个基因的拷贝数。最近的研究发现基因拷贝数变化是疾病发生和进程的主要调节机制。这个芯片编码转录因子、受体和调节细胞周期和DNA损伤修复等过程的生长因子这些基因来自主要文献评论和公共数据库中与人类肺癌生物学相关的最频繁扩增或缺失的基因。这个芯片可做为帮助分类肺癌样本基因型并验证表型生物标记的有效工具。这个芯片可以使每个基因在每个样本中有四个重复，同时包含一个稳定的多拷贝参考实验，通过适当的DNA插入标准化精确检测拷贝数。简单的产品模式和操作程序让任何一个具备实时定量PCR仪的实验室都可进行常规可靠的拷贝数检测。
qBiomarker拷贝数PCR芯片用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
提供96孔板，384 -(4×96)板，和100 孔。

Non-Small Cell Lung Cancers (NSCLC): CCND1, CDKN2A, CSMD1, EGFR, KRAS, MET, MYC, PIK3CA.
Lapatinib Sensitivity: CDKN2A.
AKT & PI-3-Kinase Signaling: AKT1, PIK3CA, PTEN.
Apoptosis: TNFRSF6B.
Cell Adhesion & Cytoskeleton: CSMD1, CTNND1.
Cell Cycle: CCND1, CDKN2A, MDM2.
Growth Factors: VEGFA.
RAS Signaling: KRAS.
Transcription Factors: MYC, NKX2-1, NKX2-8, RB1, SKIL, SOX2, TFDP1.
Tyrosine Kinase Receptors: EGFR, IGF1R, KIT, MET, PDGFRA, RB1.