阿尔茨海默病拷贝数PCR芯片 Alzheimer's Dis

ease Copy Number PCR Array

价格¥4800

简介Alzheimer's Disease Copy Number PCR Array
地区上海
更新日期2026年01月29日

上海英拜生物科技有限公司

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服务名称：
Alzheimer's Disease Copy Number PCR Array
提供商：
SAB

Human Alzheimer's Disease Copy Number PCR Array
The Human Alzheimer's Disease qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in Alzheimer’s disease. The cause of Alzheimer’s disease, the most common form of dementia, has not determined, but it is associated with the accumulation of plaques, tangles, or deposits of amyloid beta protein. It has no treatment or cure, but early diagnosis using cognitive tests and brain scans can help in preparing for care. Several de novo genomic rearrangements, including copy number variations (CNV), have been identified at specific gene loci in patients with Alzheimer’s. The genes on this array encode cytoskeletal components, ion channels, G-protein coupled receptors, proteases, and transcription factors. These proteins regulate processes such as amyloid plaque clearance (including via an immune response), axon growth, axon guidance, central nervous system development (including dysfunction and maintenance), intracellular transport, oxidative stress responses, synaptic plasticity and synaptic transmission. Genes were chosen from the most frequently amplified or deleted genes relevant to Alzheimer’s disease based on a critical review of the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array facilitates the analysis of each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allows routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument. The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease. 96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available

Deletions: ERBB4, NRXN1.
Duplications: APP, CHRNA7, CR1, CYFIP1, NIPA1, NIPA2, OR4K2, TUBGCP5.
Behavior, Cognition, Learning & Memory: APP, ATXN1, CHRNA7, NRXN1.
Membrane Potential / Nerve Impulse: APP, ATXN1, CHRNA7, ERBB4, KLK6, NRXN1.
Amyloid Plaque Formation & Clearance: APP, CR1, CSMD1, FPR2, HLA-DPB1, KLK6.
Neurogenesis: APP, CYFIP1, NRXN1, RELN.
Central Nervous System Development: ERBB4, KLK6, NIPA1, NIPA2, RELN.
Axon Growth & Guidance: CYFIP1, RELN.
Neurotransmitter Receptor: CHRNA7.
Ion Transport: CHRNA7, NIPA1, NIPA2, SLC30A3, SLC35F2.
Immune Response: CR1, CSMD1, FPR2, HLA-DPB1.
Oxidative Stress Response: GSTT1.
Transcriptional Regulation: APP, ATXN1, ERBB4, MEOX2
G-Protein Coupled Receptors: FPR2, OR4K2.
Proteases: IMMP2L, KLK6, RELN.
Intracellular Transport: DOPEY2, IMMP2L.
Cell Adhesion & Cytoskeleton: CYFIP1, NRXN1, TUBGCP5
RNA Binding Proteins: ATXN1, HNRNPCL1.

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文献和实验

相关实验

Analyzing Copy Number Variation Using SNP Array Data: Protocols for Calling CNV and Association Tests
from Illumina SNP array data using PennCNV and performing association analysis using R and PLINK. Curr. Protoc. Hum. Genet . 79:1.27.1?1.27.15. © 2013 by John Wiley & Sons, Inc. Keywords: copy number variations (CNV); CNV calling; genome
Targeted Screening and Validation of Copy Number Variations
. Methods covered include fluorescence in situ hybridization (FISH), quantitative real-time PCR (qPCR), paralogue ratio test (PRT), molecular copy-number counting (MCC), and multiplex PCR-based approaches, such as multiplex amplifiable probe hybridization
Detection of Copy Number Variation Using SNP Genotyping
have been identified as an important source of normal genomic variation as well as disease-causing variation. The ability to perform genome-wide discovery of large copy number variants (CNVs) has been facilitated by advances in two technologies – array comparative

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阿尔茨海默病拷贝数PCR芯片 Alzheimer's Dis

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