TET1 Antibody, Mouse Monoclona

类别: Antibodies

描述: Mouse monoclonal to TET1.TET1 is a methylcytosine dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Methylation at the C5 position ofcytosine bases is an epigenetic modification of the mammalian genome which plays an important rolein transcriptional regulation. TET1 might initiate a process leading to cytosine demethylation throughdeamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylatedcytosine by the base excision repair system. TET1 preferentially binds to CpG-rich sequences atpromoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of5mC and 5hmC at gene promoters, it may regulate the gene silencing induced by cytosinemethylation. It has been shown that TET1 plays an important role in embryonic stem cellsmaintenance and regulating the balance between pluripotency and lineage commient.

别名: anti-TET1 antibody,anti-Methylcytosine dioxygenase TET1 antibody,anti-CXXCtype zinc finger protein 6 antibody,anti-Leukemiaassociated protein with a CXXC domain antibody,anti-Teneleven translocation 1 gene protein antibody,anti-CXXC6 antibody,anti-KIAA1676 antibody,anti-LCX antibody

应用稀释比例: WB:1:1000-1:3000

免疫原: multiple regions of human TET1

分子量: 235

防腐剂: 0.01% NaN3

纯度: Ascites

研究领域: Metabolism Research

UniProt ID: Q8NFU7

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.