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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human IL-17/IL-17A
- 库存：
10
- 供应商：
研卉生物
- 规格：
50ug
Recombinant Human IL-17/IL-17A (C021)
产品说明(Description)
Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Gly24-Ala155 is expressed.
Accession #: Q16552
Known as: Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
制剂（Formulation）
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
质量控制（Quality Control）
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Bioactivity: Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells.
The ED50 for this effect is 1-7 ng/ml.
复溶（Reconstitution）
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
背景（Background）
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
自1993年首次发现IL-17A以来，现已有6个IL-17家族细胞因子被发现，分别为IL-17A、IL-17B、IL-17C、IL-17D、IL-17E和IL-17F。IL-17是T细胞诱导的炎症反应的早期启动因子，可以通过促进释放前炎性细胞因子来放大炎症反应。IL-17与受体结合后，迅速招募Act1并泛素化TNF-受体相关因子6 (TRAF6)，进而通过MAP 激酶途径和核转录因子kB (Nuclearfactor kB, NF-kB)途径发挥其生物学作用。Th17细胞能够分泌产生IL-17A、IL-17F、IL-6以及TNFα等，这些细胞因子可以集体动员、募集及活化中性粒细胞。Th17细胞产生的IL-17能有效地介导中性粒细胞动员的兴奋过程，从而有效地介导了组织的炎症反应。曾发表在《Nature》中的一项研究报告指出，IL-17失调与急性炎症反应密切相关，可引起银屑病、类风湿性关节炎和多发性硬化症等疾病产生。IL-17家族成员都与炎症的发生相关，其中IL-17F来源和功能与IL-17A最为相似，同样具有和IL-17A相同的抗感染作用，并且表现出相对较低的促炎活性。IL-17A和IL-17F以同源二聚体的形式存在，但也可以作为一种异源二聚体产生，三种形式均与IL-17 RA和IL-17 RC异二聚体结合诱导信号。其中，IL-17A同源二聚体诱导信号最强，其次是IL-17A/F，最后是IL-17F同源二聚体。重组人源化抗IL-17A单克隆抗体就是通过与IL-17A高亲和力结合并选择性地阻断IL-17A与其受体IL-17RA/IL-17RC的结合，从而阻断下游信号通路的激活和炎性因子的释放，能有效地缓解自身免疫性疾病的症状。
FOR RESEARCH USE ONLY仅限科学研究
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文献和实验9.18 Nature 子刊：IL- 17 激活 NOTCH 信号通路，参与细胞增殖
感受低温的功能，并在小鼠的背根神经节（DRG）得到实验证明。该工作发现谷氨酸受体蛋白 GLR- 3 /Gluk2 能够感受低于 18 摄氏度的低温，是目前科学界发现的首个低温冷受体，并且其感受低温的功能不受其离子通道功能的影响，是偶联下游 G 蛋白来行使其冷信号传递功能。原文检索：A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene ② Nature 子刊：IL- 17 激活 NOTCH 信号通路，参与细胞增殖近年来的研究发现，Th17
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