Charybdotoxin - ChTx

Charybdotoxin - ChTx
K_Ca²⁺ channel blocker

Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca²⁺ activated K⁺ channels K_Ca1.1 in nanomolar concentrations (IC₅₀~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocksK_Ca3.1 (IC₅₀ 5 nM), K_v1.2 (IC₅₀ 14 nM), K_v1.3 (IC₅₀ 2.6 nM) and K_v1.6 (IC₅₀ 2 nM) channels.

Product specifications

AA sequence: H-Pyr-Phe-Thr-Asn-Val-Ser-Cys⁷-Thr-Thr-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys²⁸-Met-Asn-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Ser-OH
(Disulfide bonds between Cys⁷-Cys²⁸, Cys¹³-Cys³³, and Cys¹⁷-Cys³⁵)
Length (aa): 37
Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇
Molecular Weight: 4295.90 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 95751-30-7
Source: Synthetic
Purity rate: > 97%

11CHA001-00050	Charybdotoxin	0.05mg
11CHA001-00100	Charybdotoxin	0.1mg
11CHA001-00500	Charybdotoxin	0.5mg
11CHA001-01000	Charybdotoxin	1mg