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- Smartox Biotechnology
- 08MAG001
- 2025年12月29日
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Catalog N° 08MAG001
Margatoxin
Kv1.3 selective blocker
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxinpreferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.
Margatoxin technical information
AA sequence: Thr-Ile-Ile-Asn-Val-Lys-Cys7-Thr-Ser-Pro-Lys-Gln-Cys13-Leu-Pro-Pro-Cys17-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys29-Met-Asn-Gly-Lys-Cys34-Lys-Cys36-Tyr-Pro-His-OH
(Disulfide bonds between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36)
Length (aa): 39
Formula: C178H286N52O50S7
Molecular Weight: 4179.03 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [145808-47-5]
Source: Synthetic
Purity rate: > 97 %
| 08MAG001-00100 | Margatoxin | 0.1mg |
| 08MAG001-00100 | Margatoxin | 0.5mg |
| 08MAG001-01000 | Margatoxin | 1mg |
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文献和实验酸，甘露碱[见于毛根] mannose|甘露糖 mannosidase|甘露糖苷酶 mannuronic acid|甘露糖醛酸 maravirus|玉米雷亚多非纳病毒组 marburg virus|马堡病毒 margatoxin|玛格（斑蝎）毒素 marginal initial|边缘原始细胞[见于植物] marmoset|绒猴 mash|醪
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