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DNA/RNA Damage Monoclonal Anti

body (Clone 15A3)
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  • 询价
  • Cayman已认证
  • USA
  • 10011446
  • 2025年07月10日
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    深圳欣博盛生物科技有限公司
    代理商
    16 年钻石会员

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    • 供应商：

      Neobioscience

    • 保存条件：

      -20

    • 规格：

      100 µg

    Antigen: 8-hydroxy guanosine-BSA and casein conjugates • Host: mouse, clone 15A3 • Cross Reactivity: (+) 8-hydroxy-2-deoxy guanosine, 8-hydroxy guanine, and 8-hydroxy guanosine • Applications: ELISA, IAC, and IHC • Isotype: IgG2b • 8-hydroxy guanine, 8-hydroxy-2’-deoxy guanonsine, and 8-hydroxy guanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2’-guanosine, produced by RONS including hydroxyl radical peroxynitrite, induces G to T transversions, which is one of the most frequent somatic mutations. 8-hydroxy guanine DNA base damage arises from radical-induced hydroxylation and cleavage reactions of the purine ring. 8-hydroxy guanosine also induces a mutagenic transversion of G to T in DNA.

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