DNA/RNA Damage Monoclonal Anti

Antigen: 8-hydroxy guanosine-BSA and casein conjugates • Host: mouse, clone 15A3 • Cross Reactivity: (+) 8-hydroxy-2-deoxy guanosine, 8-hydroxy guanine, and 8-hydroxy guanosine • Applications: ELISA, IAC, and IHC • Isotype: IgG2b • 8-hydroxy guanine, 8-hydroxy-2’-deoxy guanonsine, and 8-hydroxy guanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2’-guanosine, produced by RONS including hydroxyl radical peroxynitrite, induces G to T transversions, which is one of the most frequent somatic mutations. 8-hydroxy guanine DNA base damage arises from radical-induced hydroxylation and cleavage reactions of the purine ring. 8-hydroxy guanosine also induces a mutagenic transversion of G to T in DNA.