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文献和实验-inflammatory drugs such as diclofenac did not only suppress the prostaglandin but also the F2 -IsoP pathway. Microdialysis allows the “near-in vivo” measurement of prostanoid mediators, released in the interstitial space of the dermis under inflammatory
Enzyme Immunoassay of Isoprostanes
, and excreted. It is now well recognized that isoprostane levels, most commonly those of 15F2t -isoprostane (formerly denoted 8-iso-prostaglandin F2 α ) in blood or urine, are useful biomarkers for the assessment of oxidative stress, which is a major risk factor
Isoprostanes (IPs) are a recently discovered complex group of stable prostaglandin-like molecules formed by the free radical-catalyzed peroxidation of polyunsaturated fatty acids (1 ). F2 -isoprostanes (F2 -IPs) are formed by the oxidation
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