HIF-1α (C-Term) Polyclonal Ant

Antigen: HIF-1α C-terminal amino acids 809-826 • Host: rabbit • Cross Reactivity: (+) human, mouse, and simian HIF-1α • Application(s): (+) WB; (-) ICC and IP • HIF-1α is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where, with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.