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- Enzo Life Sciences
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- 2025年07月16日
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Neobioscience
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文献和实验. Substitution of one or both strands of a siRNA duplex by 2'-deoxy or 2'-O-methyl oligoribonucleotides abolished silencing in fly extract (Elbashir et al. 2001c). In mammalian cells, however it seems possible to substitute the sense siRNA by a 2'-O-methyl
duplex by 2'-deoxy or 2'-O-methyl oligoribonucleotides abolished silencing in fly extract (Elbashir et al. 2001c). In mammalian cells, however it seems possible to substitute the sense siRNA by a 2'-O-methyl oligoribonucleotide (Ge et al. 2003)Useful
of the antisense strand. All other hairpin RNAs behaved very similar to siRNA duplexes. Substitution of one or both strands of a siRNA duplex by 2''-deoxy or 2''-O-methyl oligoribonucleotides abolished silencing in fly extract (Elbashir et al. 2001c
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