- ￥1080 - 16905
- PROSPEC
- 以色列
- cyt-426
- 2025年07月19日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
ProNGF
- 库存：
部分小规格有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
2ug/10ug/100ug
| 规格： | 2ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 10ug | 产品价格： | ￥2415.0 |
| 规格： | 100ug | 产品价格： | ￥16905.0 |
CATALOGUE NUMBER
CYT-426
SYNONYMS
DESCRIPTION
Pro-NGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 224 amino acids and having a molecular mass of 25 kDa.
ProNGF Human Recombinant is purified by proprietary chromatographic techniques.
SOURCE
PHYSICAL APPEARANCE
FORMULATION
ProNGF was lyophilized from a 0.2 μM filtered solution of 20m Tris-HCL, 0.5M NaCl, 5% Trehalose, 5% Mannitol. 0.01% Tween-80 and 1mM EDTA pH-8.
SOLUBILITY
It is recommended to reconstitute the lyophilized ProNGF in distilled water to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
STABILITY
Please prevent freeze-thaw cycles.
PURITY
AMINO ACID SEQUENCE
MEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNI
TVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRS
SSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFET
KCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTAC
VCVLSRKAVRRA.
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文献和实验- Fahnestock M, Michalski B, Xu B. Coughlin MD. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci. 2001;18(2):210-220.
- Hempstead BL. The many faces of p75NTR. Curr Opin Neurobiol. 2002;12(3):260-267.
- Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science. 2001;294(5548):1945-1948.
- Massa SM, Xie Y, Yang T, et al. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci. 2006;26(21):5288-5300.
- Volosin M, Song W, Almeida RD, et al. Interaction of survival and death signaling in basal forebrain neurons: Roles of neurotrophins and proneurotrophins. J Neurosci. 2006;26(29):7756-7766.
Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
The development of efficient recombinant protein production processes can be a critical factor in whether or not a pharmaceutical therapeutic protein can enter human clinical trials and ultimately the marketplace. This is especially true
略称NGF。在将小鼠肉瘤180移植于3日龄鸡胚体壁时，与移植片连接的脊髓感觉神经节及交感神经节增大20％—40％，基于比克尔（E.D.Bueker，1948）的这一发现，科恩（S.Cohen，1954）等从小鼠肉瘤180和37中成功地分离出具有同一活性的核蛋白质，以后从蛇毒中分离出具有千倍活性（Cohen，R.Levi-Montalcini，1956）和从小鼠颚下腺分离出具有万倍活性的蛋白质（Cohen，1960），这种蛋白质被称为神经生长因子。科恩等认为，其有效成分是分子量约为2.2万
The large number of cytokines and growth factors implicated in the regulation of liver regeneration has led to the possibility of using these molecules in therapy, namely, in the case of recombinant human hepatocyte growth factor (rhHGF
技术资料