micrOFF™ miRNA inhibitor（miRNA

特异性针对成熟miRNA序列，采用稳定性特殊设计，通过化学方法合成的miRNA抑制剂，能够竞争性与成熟miRNA结合，阻止其正常行使功能。

micrOFF™ miRNA inhibitor是化学合成的，经过特殊修饰的miRNA抑制剂，通过特异性地与成熟miRNA分子结合而抑制其作用，可以削弱细胞中miRNA导致的基因沉默效应，进行miRNA功能缺失性(loss-of-function)研究。

micrOFF™ miRNA inhibitor只需用转染试剂包裹即可转染进入细胞，无需构建载体的繁琐操作，无需病毒防护方面的担忧，用转染对照即可观察其转染效率。锐博生物提供miRBase数据库中人、小鼠、大鼠的所有miRNA inhibitor，并不断补充更新，其他物种的miRNA inhibitor需定制。




应用实例：

1) Wu J, Wu G, Lv L, Ren YF, Zhang XJ, Xue YF, Li G, Lu X, Sun Z, Tang KF.MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1.Carcinogenesis. 2012 Jan 17.

2) Zheng B, Liang L, Huang S, Zha R, Liu L, Jia D, Tian Q, Wang Q, Wang C, Long Z, Zhou Y, Cao X, Du C, Shi Y, He X.MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers.Oncogene. 2011 Dec 19.

3) Du J, Wang J, Tan G, Cai Z, Zhang L, Tang B, Wang Z.Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation .Med Oncol. 2012 Feb 7

4)Wang T, Li M, et al.MicroRNAs miR-27a and miR-143 Regulate Porcine Adipocyte Lipid Metabolism.Int J Mol Sci. 2011;12(11):7950-9. Epub 2011 Nov 15.

5)Li L, Shi JY, Zhu GQ, Shi B.MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cellsJ Cell Biochem. 2011 Nov 17.