- ￥3000 - 3999
- Abbiotec
- 美国
- 250647
- 2025年07月08日
- E, WB, IHC
- Rabbit
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Fe65.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆抗体
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 宿主：
Rabbit
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
Fe65 Protein
- 抗体英文名：
Fe65 Protein Antibody
- 抗体名：
Fe65 Protein Antibody
- 规格：
0.1 mg
Fe65 Protein Antibody产品详细介绍：
| 产品名称： | Fe65 Protein Antibody |
| 说明书： | http://www.abbiotec.com/antibodies/fe65-protein-antibody【参考图片】 |
| 货号： | 250647 |
| 规格： | 0.1 mg |
| 产品描述： | Fe65 (Amyloid beta A4 precursor protein-binding family B member 1) is an adaptor protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precurson protein (APP) intracellular domain. APP functions as a cystosolic anchoring site that prevents Fe65 nuclear translocation. Following exposure to DNA damaging agents, Fe65 is released from the membrane and translocates to the nucleus to induce apoptosis. It acts by binding to Tyr-142-phosphorylated histone H2AX at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Fe65 is required for histone H4 acetylation at DSBs. Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60 probably explains the transcription activation activity of Fe65. Fe65 plays a role in the pathogenesis of Alzheimer's disease. It also blocks cell cycle progression by down-regulating thymidylate synthase expression. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Fe65. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别名： | Fe65 protein; Protein Fe65; Amyloid beta A4 precursor protein-binding family B member 1; APBB1; RIR |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Protein A Purification of Antibody
1. Reagents(1) Affi-gel Protein-A Agarose (BioRad #153-6153)(2) MAPS II Binding Buffer (BioRad # 153-6161)(3) 0.314 g/ml diH2O(4) MAPS II Elution Buffer (BioRad #153-6162)(5) 0.023 g/ml diH2O(6) MAPS II Regeneration Buffer (BioRad #153-6166(7) 1M
ANTIBODY BINDING TO PROTEIN A AND PROTEIN G
Protein A, derived from the cell wall of Staphylococcus aureus , and protein G, derived from the cell wall of certain strains of b -hemolytic Streptococcci , binds the Fc region
Antibody Purification: Affinity Chromatography Protein A and Protein G Sepharose
Affinity chromatography relies on the reversible interaction between a protein and a specific ligand immobilized in a chromatographic matrix. The sample is applied under conditions that favor specific binding to the ligand as the result
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