peptide corresponding to a sequence at the N-terminus of human NMDAR1.
亚型:
Rabbit Polyclonal IgG
形态:
液态
保存条件:
保存于-20℃
克隆性:
多克隆
标记物:
无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种:
Hu, Mo, Rat
保质期:
按说明书条件可保存1-2年
抗原来源:
见详细说明资料
目录编号:
PL0401129
级别:
超纯
库存:
大量
供应商:
华拓生物
宿主:
Rabbit
应用范围:
WB: 1:100-500 IHC: 500-1000
浓度:
1mg/ml
靶点:
NMDAR1
抗体英文名:
NMDAR1 Antibody
抗体名:
NMDAR1抗体
规格:
0.1ml
NMDAR1 Antibody
Cat#:PL0401129
Isotype:Rabbit Polyclonal IgG
Immunogen:peptide corresponding to a sequence at the N-terminus of human NMDAR1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor. NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell.