IMUBIND® FSAP Marburg I ELISA

INTENDED USE
The IMUBIND® FSAP Marburg I ELISA is intended for the detection of the Marburg I (MI) variant of factor seven activating protease (FSAP) in human plasma. The assay is intended for research use only.

EXPLANATION OF THE TEST
Factor Seven Activating Protease (FSAP, Factor VII activating protease, FVII activating protease) is a potent activator of factor VII independent of tissue factor and an activator of pro-urokinase. FSAP playing a dual role, clot formation via factor VII activation and clot degradation via prourokinase activation, holds a key position in the delicate balance of the hemostatic system.

A mutant variant of FSAP with a single nucleotide polymorphism (SNP) has been identified, termed “Marburg I” (FSAP MI). The prevalence of the heterozygous FSAP MI genotype (1601 G/A) has been reported to be in a range of 4 to 9 % in Caucasian populations. The FSAP Marburg I variant shows a reduced ability to activate prourokinase, whereas its ability to activate Factor VII is normal.3 It seems likely that FSAP Marburg I, due to the resulting hemostatic imbalance, may promote the development of thromboembolic diseases. The FSAP Marburg I variant was found to have
an effect upon the risk for cardiovascular heart disease in those patients with elevated levels of cholesterol and triglyceride.4 In addition, the FSAP Marburg I variant was found to be a significant risk predictor for the evolution and progression of carotid stenosis5 and associated with idiopathic venous thromboembolism.6