MMP-9/MMP-13 Inhibitor I

The Matrix Metalloproteinase (MMP) and Tissue Inhibitor of Metalloproteinase (TIMP) Genes: Transcriptional and Posttranscriptional Regulation, Signal

(Table 1 ). The enzymatic activity of MMP family members is controlled by a group of inhibitor proteins known as the Tissue Inhibitors of Metalloproteinases (TIMPs), which consist of four family members (Table 2 ). Whereas all four TIMPs can inhibit

细胞信号通路相关文献

invasion. In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane

【共享】【申请加分】国外癌症基础研究的主要进展

编码的蛋白质ING的水平似乎与肿瘤侵袭性强度相对应，蛋白水平越低，神经胶质瘤恶性程度越高。，研究人员还描述了ING4是如何抑制向肿瘤提供营养的新血管生长。ING（INhibitor of tumor Growth，肿瘤生长抑制因子）是肿瘤抑制基因p53活动所必需的一个蛋白家族。由麻萨诸塞综合医院放射肿瘤学部Steele实验室的Igor Garkavtsev博士领导的研究小组搜索了一个基因数据库，目的是识别出与早先识别出的ING1结构类似的基因。 　　研究小组首先检查了50个处于各种恶性级别的肿瘤