- ¥4130
- AssayPro
- 0.19 ng/ml
- 美国
- EM5001-1
- 2026年04月13日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 供应商：
AssayPro
- 检测范围：
0.19 ng/ml
- 检测方法：
ELISA
- 应用：
血清、血浆、细胞培养上清液、尿液、唾液、牛奶
- 样本：
50 μl
- 规格：
96 wells
β2微球蛋白β2-MG酶联免疫试剂盒
β2-Microglobulin (β2M) is a small serum protein that constitutes the light chain of the major histocompatibility class I human leukocyte antigen (HLA class I), an integral membrane protein involved in the immune response. The protein is 99 amino acid residues in length and has molecular mass of 12 kDa (1 - 4). β2M is released from the cell surface of HLA class I into the serum and carried to the kidneys for degradation and secretion (5). In chronic renal failure, β2M accumulates as insoluble amyloid aggregates and causes arthralgias, destructive osteoarthropathies, carpal tunnel syndrome and dialysis-related amyloidosis (6 - 8). Elevated serum β2M levels are associated with poor prognosis in multiple myeloma and lymphoma (9 - 12).
Principle of the Assay
The AssayMax Human β2-Microglobulin ELISA kit is designed for detection of human β2-microglobulin in plasma, serum, milk, saliva, urine and cell culture supernatants. This assay employs a quantitative sandwich enzyme immunoassay technique that measures β2-microglobulin in less than 4 hours. A polyclonal antibody specific for β2-microglobulin has been pre-coated onto a microplate. β2-microglobulin in standards and samples is sandwiched by the immobilized antibody and biotinylated polyclonal antibody specific for β2-microglobulin, which is recognized by a streptavidin-peroxidase conjugate. All unbound material is then washed away and a peroxidase enzyme substrate is added. The color development is stopped and the intensity of the color is measured.
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文献和实验。如何判断手术效果和评价预后仍是目前面临的一个问题。β2微球蛋白(β2microglobulin，β2 MG)是人类白细胞抗原(human leukocyte antigen,HLA)I类分子编码的轻链即β链部分。它是诊断早期肾功能不全的一项重要指标。研究表明，肿瘤的发生发展与β2 MG的关系密切。近年来，β2 MG也被作为恶性肿瘤的非特异性指标应用于临床［1］。据此，本研究利用免疫比浊法检测大肠癌和胃癌患者手术前后血清β2 MG含量变化，探讨其用于大肠癌和胃癌辅助诊断、疗效判断的临床意义。
subsets, all noncovalently associated with 12 kd beta 2 microglobulin Function: restrict T cell responses to certain antigens; may mediate thymic T cell development Positive staining (normal): cortical thymocytes (70%), activated T cells
Genetic and Pharmacologic Models for Type 1 Diabetes
‐Williams, E.E. , Serreze, D.V. , Charlton, B. , Johnson, E.A. , Marron, M.P. , Mullbacher, A. , and Slattery, R.M. 2001. Transgenic rescue implicates β2‐microglobulin as a diabetes susceptibility gene in NOD mice. Proc. Natl. Acad. Sci. U.S.A. 98: 11533
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