- ¥4130
- AssayPro
- 1.5 ng/ml
- 美国
- EK1001-1
- 2025年12月26日
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- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
AssayPro
- 检测范围：
1.5 ng/ml
- 检测方法：
ELISA
- 应用：
细胞培养上清液、尿液、唾液、牛奶
- 样本：
50 μl
- 规格：
96 wells
AssayMax Human Kininogen (HMW) ELISA Kit
高分子量激肽原KNG酶联免疫试剂盒
高分子量激肽原KNG酶联免疫试剂盒
Introduction
High molecular-weight kininogen (HK) is a plasma protein coagulation cofactor serving for the activation of zymogens prekallikrein, Factor XII, and Factor XI and is also a substrate of each of their proteolytic forms. It circulates as a complex with these zymogens and links the plasma coagulation, fibrinolysis, complement activation, and blood pressure control. HK is produced by the liver and weighs 120 kDa with 626 amino acids. Its plasma concentration ranges from 55 to 90 μg/ml and (1, 5). HK exhibits anticoagulant properties and is a strong inhibitor of cysteine proteases. Upon cleavage by kallikrein, the released active peptide bradykinin mediates NO release, vasodilation, hypotension, and pain. The remaining cleaved HK (HKa) exhibits antiadhesive and antiangiogenic activity, enhancing cell-associated fibrinolysis and releasing cytokines and chemokines to enhance inflammation. Patients with HK deficiency exhibit abnormal surface-mediated activation of fibrinolysis (6, 7).
Principle of the Assay
The AssayMax Human Kininogen (HMW) ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for detection of human kininogen in urine, saliva, milk, and cell culture supernatant samples. This assay employs a quantitative sandwich enzyme immunoassay technique that measures human kininogen in less than 4 hours. A polyclonal antibody specific for human kininogen has been pre-coated onto a 96-well microplate with removable strips. Kininogen in standards and samples is sandwiched by the immobilized antibody and the biotinylated polyclonal antibody specific for kininogen, which is recognized by a streptavidin-peroxidase conjugate. All unbound material is then washed away and a peroxidase enzyme substrate is added. The color development is stopped and the intensity of the color is measured.
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AssayPro—Human Kininogen (HMW) ELISA Kit（高分子量激肽原KNG酶联免疫试剂盒）
¥4130
