(3S,6R,7S,8S,12Z,15S,16E)-1,3,

1) Cat. No.: TRC-T296750; 2) Chemical Name: (3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-Tetrakis-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one; 3) CAS No.: 193146-51-9; 4) Mol. Formula: C51H101NO5SSi4; 5) Mol. Weight: 952.76; 6) Packing Size: 0.5mg / 5mg; 7) Appearence: Off-Yellow Oil; 8) Application Notes: An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.; 9) Synonym: ; 10) Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate; 11) Storage condition: ; 12) References: Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999), Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)